- Terpenes (isoprenoids) are small molecules that consist of repeating units of a compound called isoprene.
- Often terpenes in the plant kingdom serve as evolutionary defence mechanisms to ward off predators and pathogenic microbes such as fungi and bacteria.
- When terpenes are modified chemically, such as by oxidation or rearrangement of the carbon skeleton, the resulting compounds are generally referred to as terpenoids.
- Recent studies have found that some terpenes are said to modulate the physiological and psychoactive effects of cannabis. They also contribute to given cannabis its unique bouquet and flavor…
SuperCBDx has many more medical applications because it is high CBD/low THC with minimum psycho activity.
Common Terpenes in Marijuana
So far SuperCBDx carries amounts for all the common terpenes (except for two that were not a part of the terpene profile test compounds).
In purple are the amounts mg/gr for the terpene profile for SuperCBDx
|Alpha-pinene||Pine||Anti-inflammatory, bronchodilator, memory enhancer .42 mg/gr|
|Beta-caryophyllene||Black pepper||Anti-anxiety, anti-inflammatory, antimalarial, CB2 activity .17 mg/gr|
|Beta-myrcene||Hops||Sedative, muscle relaxant, hypnotic, anti-inflammatory, analgesic .30 mg/gr|
|Limonene||Lemons||Anti-anxiety, anti-cancer, antibacterial .06 mg/gr|
Anti-anxiety, sedative, anaesthetic, analgesic, anticonvulsant
|Nerolidol||Oranges||Sedative, antimalarial .06 mg/gr|
It appears that the terpenoid compounds in marijuana have clinical effects, that is, they work with the cannabinoids to help with symptoms. This is called synergy or the “entourage effect“, a term coined by Raphael Mechoulam, a prominent cannabis researcher. Synergy and the entourage effect mean that “the interaction of two or more substances produces combined effects that are greater than the sum of their separate effects”.
Here is a list of some of the terpenoids found in cannabis and their clinical effects:
Limonene – .06 mg/gr this terpenoid is also found in lemons; it works with CBD to give antidepressant effects and stimulates the human immune system; in mice it was found to work with CBD to decrease anxiety and depression; works synergistically with CBD and CBG to kill breast cancer cells; works with THC to decrease GERD (reflux)
Myrcene – .30 mg/gr this terpenoid is also found in hops; it works with CBD to block inflammation; works as pain-killer in mice studies when combined with CBD and THC; is sedating and was found to potentiate sleep time synergistically with THC
Alpha-pinene – .42 mg/g terpenoid also found in pine needles; it works as anti-inflammatory when combined with CBD; bronchodilation (opens lung airways) when combined with THC in human studies; anti-MRSA (Staph infection) with CBD, CBG (cannabigerol) and CBN (cannabinol); works as wide spectrum antibiotic
Linalool – .08 mg/gr this terpenoid is also found in lavender; has anti-anxiety effects with CBD and maybe CBG; causes sedation in mice studies; works as local anesthetic with THC; anticonvulsant and anti-glutamate with CBD, THCV and CBDV
Nerolidol – .06 mg/gr this terpenoid is also found in oranges; appears to have sedative qualities; inhibits fungal growth with CBC (cannabichromene)
Beta-caryophyllene – .17 mg/Ngr this terpenoid is found in Echinacea; it has anti-inflammatory properties with CBD; protects stomach cells with THC; binds to CB2 receptors with THC giving analgesic and anti-inflammatory properties
Phytol –Not tested in terpene profile this terpenoid is also found in green tea; it appears to block the breakdown of GABA (a neurotransmitter that helps to control anxiety)
Caryophyllene oxide - Not tested in terpene profile – terpenoid also found in lemon balm; acts as an anti-fungal
The medical effects of the interaction of terpenoids with the cannabinoids is a big area of research and being investigated by many labs. As research is published and our knowledge grows, patients will benefit from being able to select the specific cannabis medication that contain the compounds that work best for their symptoms.